Associations of Circulating Irisin with FNDC5 Expression in Fat and Muscle in Type 1 and Type 2 Diabetic Mice

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Decreased irisin secretion contributes to muscle insulin resistance in high-fat diet mice.

AIMS Recent studies have revealed the relationship between irisin and insulin signaling, while positive associations of muscle FNDC5 with insulin resistance is observed. However, the functional mechanism of irisin on muscle insulin resistance is still obscure. This study aims to investigate the effect of irisin on muscle insulin action. METHODS Diabetic mouse model was established by high fat...

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Circulating Irisin Is Reduced in Male Patients with Type 1 and Type 2 Myotonic Dystrophies

Context Myotonic dystrophies (DM) are dominantly inherited muscle disorders characterized by myotonia, muscle weakness, and wasting. The reasons for sarcopenia in DMs are uncleared and multiple factors are involved. Irisin, a positive hormone regulator of muscle growth and bone, may play a role. Objectives To investigate (1) circulating irisin in a series of DM1 and DM2 male patients compared...

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ژورنال

عنوان ژورنال: Biomolecules

سال: 2021

ISSN: 2218-273X

DOI: 10.3390/biom11020322